Fig. S5.

Losartan dose finding. The dose of losartan used in drug infusion experiments was based on the ability to block angiotensin II infusion-induced increases in LV systolic pressure, in a manner comparable to TRV120023 at a dose of 100 μg⋅kg^–1⋅min^–1. All mice were given a continuous infusion of angiotensin 100 ng⋅kg^–1⋅min^–1 for 8 min, during which time they were coadministered saline, losartan 2.5 mg⋅kg^–1⋅min^–1, or losartan 5 mg⋅kg^–1⋅min^–1. Error bars reflect SEM.