. 2016 Nov 28;113(50):14426–14431. doi: 10.1073/pnas.1609308113

Table S2.

β-arrestin KO vs. WT response to LV loading

LVEDP, mmHg	LVEDV, μL	LVESV, μL	Stroke volume, μL	Stroke work, μL⋅ mmHg	dP/dtmax, mmHg/s	Arterial elastance, mmHg/μL	Systolic pressure, mmHg
WT (n = 20)
5	42.00 ± 2.17	19.49 ± 1.20	22.51 ± 1.55	2,548.4 ± 221.3	11,686 ± 663	6.99 ± 0.50	157.3 ± 3.9
10	50.30 ± 1.82^*	25.42 ± 1.08^*	24.88 ± 1.42^*	2,794.5 ± 199.7^*	11,799 ± 634	6.64 ± 0.48	159.7 ± 3.8
12	53.62 ± 1.75^*	27.79 ± 1.13^*	25.83 ± 1.43^*	2,892.9 ± 196.0^*	11,844 ± 628	6.49 ± 0.47	160.6 ± 3.8
14	56.94 ± 1.73^*	30.16 ± 1.23^*	26.77 ± 1.47^*	2,991.3 ± 195.4^*	11,889 ± 626	6.35 ± 0.47	161.5 ± 3.9
16	60.25 ± 1.77^*	32.53 ± 1.37^*	27.72 ± 1.55^*	3,089.7 ± 197.9^*	11,934 ± 628	6.21 ± 0.48^*	162.5 ± 4.0^*
18	63.57 ± 1.86^*	34.90 ± 1.54^*	28.67 ± 1.65^*	3,188.1 ± 203.4^*	11,979 ± 634	6.06 ± 0.49^*	163.4 ± 4.2^*
20	66.89 ± 2.00^*	37.27 ± 1.73^*	29.62 ± 1.78^*	3,286.5 ± 211.8^*	12,025 ± 644	5.92 ± 0.50^*	164.3 ± 4.4^*
β-arrestin 1 KO (n = 15)
5	39.86 ± 3.88	21.32 ± 3.07	20.41 ± 1.12	2,120.5 ± 179.5	9,047 ± 534^†	7.20 ± 0.55	144.6 ± 4.6
10	46.39 ± 3.46^*	27.62 ± 2.91^*	20.76 ± 1.19	2,099.8 ± 161.3^†	8,875 ± 561^†	7.21 ± 0.56	143.2 ± 4.6^†
12	49.00 ± 3.34^*	30.14 ± 2.88^*	20.90 ± 1.28^†	2,091.5 ± 160.9^†	8,806 ± 596^†	7.21 ± 0.60	142.7 ± 4.8^†
14	51.62 ± 3.24^*	32.66 ± 2.86^*	21.04 ± 1.40^†	2,083.2 ± 164.5^†	8,737 ± 641^†	7.22 ± 0.64	142.1 ± 5.0^†
16	54.23 ± 3.18^*	35.18 ± 2.85^*	21.18 ± 1.55^†	2,074.9 ± 171.9^†	8,668 ± 696^†	7.22 ± 0.70	141.6 ± 5.4^†
18	56.84 ± 3.16^*	37.70 ± 2.87^*	21.32 ± 1.70^†	2,066.6 ± 182.6^†	8,600 ± 757^†	7.23 ± 0.76	141.0 ± 5.8^†
20	59.46 ± 3.17^*	40.22 ± 2.89^*	21.46 ± 1.87^†	2,058.3 ± 196.2^†	8,531 ± 823^†	7.23 ± 0.83	140.4 ± 6.2^†
β-arrestin 2 KO (n = 18)
5	38.58 ± 2.71	16.61 ± 2.26	22.92 ± 0.91	2,437.5 ± 135.9	8,910 ± 461^†	6.19 ± 0.33	145.5 ± 5.0
10	45.23 ± 2.69^*	21.41 ± 2.40^*	23.82 ± 0.80	2,565.4 ± 139.0	9,027 ± 536^†	6.26 ± 0.24	149.0 ± 4.8
12	47.88 ± 2.75^*	23.71 ± 2.34^*	24.17 ± 0.90	2,616.6 ± 156.3	9,074 ± 574^†	6.29 ± 0.25	150.4 ± 4.8
14	50.54 ± 2.83^*	26.01 ± 2.30^*	24.53 ± 1.07	2,667.7 ± 179.6	9,121 ± 615^†	6.32 ± 0.29	151.8 ± 4.9^*
16	53.20 ± 2.95^*	28.31 ± 2.27^*	24.89 ± 1.27	2,718.9 ± 206.8	9,168 ± 659^†	6.35 ± 0.35	153.2 ± 5.1^*
18	55.86 ± 3.09^*	30.61 ± 2.27^*	25.25 ± 1.49^*	2,770.1 ± 236.7^*	9,215 ± 706^†	6.37 ± 0.42	154.5 ± 5.3^*
20	58.52 ± 3.25^*^†	32.92 ± 2.29^*	25.60 ± 1.73^*	2,821.2 ± 268.3^*	9,262 ± 754^†	6.40 ± 0.50	155.9 ± 5.6^*

P < 0.05 vs. LVEDP 5 mm Hg of same genotype; ^†P < 0.05 vs. corresponding measure/LVEDP WT mice, one-way repeated-measures ANOVA with Bonferroni’s multiple comparison test. Errors reflect SEM.