Table S3.
Baseline hemodynamic parameters of mice undergoing the volume infusion protocol
| Parameter | WT (n = 27) | β-arrestin 1 KO (n = 15) | β-arrestin 2 KO (n = 18) | AT1R KO (n = 13) |
| Heart rate, bpm | 452.7 ± 10.6 | 442.4 ± 12.3 | 416.4 ± 14.2 | 429.8 ± 15.9 |
| LVESP, mm Hg | 142.5 ± 5.0 | 136.2 ± 4.8 | 136.7 ± 4.5 | 135.7 ± 4.9 |
| LVEDP, mm Hg | 7.17 ± 0.79 | 5.81 ± 0.81 | 6.06 ± 0.77 | 17.17 ± 2.32*† |
| Arterial elastance, mmHg/μL | 6.78 ± 0.59 | 6.90 ± 0.46 | 6.31 ± 0.27 | 5.31 ± 0.47 |
| Systolic function parameters | ||||
| Stroke volume, μL | 23.18 ± 1.25 | 20.50 ± 1.01 | 22.02 ± 0.76 | 27.21 ± 2.01 |
| Ejection fraction, % | 51.17 ± 2.96 | 54.09 ± 5.67 | 57.77 ± 3.26 | 40.03 ± 2.74 |
| Cardiac output, μL/min | 10,475 ± 593.9 | 9,075 ± 536.7 | 9,195 ± 472.3 | 11,667 ± 985.0 |
| Stroke work, mmHg⋅μL | 2,418 ± 169.6 | 2,118 ± 157.1 | 2,260 ± 114.7 | 2,569 ± 225.7 |
| dP/dtmax, mmHg/s−1 | 10,818 ± 493.3 | 9,158 ± 536.1 | 8,786 ± 505.2* | 9,070 ± 359.2 |
| Diastolic function parameters | ||||
| dP/dtmin, mmHg/s−1 | −9,351 ± 314.3 | −7,827 ± 379.2* | −8,017 ± 391.5* | −7,322 ± 249.7* |
| Tau, ms (Weiss) | 7.43 ± 0.15 | 7.65 ± 0.27 | 7.64 ± 0.29 | 9.29 ± 0.29*† |
| Tau, ms (Glantz) | 12.76 ± 0.41 | 12.06 ± 0.35 | 12.52 ± 0.45 | 16.45 ± 0.94*† |
*
P < 0.05 vs. WT; †P < 0.05 vs. β-arrestin 1 KO and β-arrestin 2 KO, one-way ANOVA.