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. 2016 Nov 28;113(50):E8151–E8158. doi: 10.1073/pnas.1614935113

Fig. 4.

Fig. 4.

TSG6 induces suppression of proinflammatory proteins and up-regulation of anti- inflammatory proteins in CD11b+ lung macrophages. (A) Immunoblots showing expression of proinflammatory proteins (STAT1, STAT3, and IL-1β) and anti-inflammatory proteins (arginase-1 and Chi3l3) in purified CD11b+ macrophages obtained from lungs of mice challenged with LPS for 24 h. Results are representative of two separate experiments. (B) Concentrations of proinflammatory cytokines (IL-6, TNFα, IFNγ, and IL-12p70) and anti-inflammatory cytokines (IL-10 and IL-4) in cultured supernatants of CD11b+ lung macrophages. *P < 0.05, LPS vs. LPS + TSG6. (C) Immunoblots showing expression of TSG6 and proinflammatory and anti-inflammatory proteins (pSTAT1, pSTAT3, IL-1β, Chi3l3, and arginase-1) in lung lysates of LPS-challenged WT and TSG6−/− mice. Results are representative of two separate experiments.