Table 3.
Top hits in nSL analysis of P. falciparum ancestral-like population
| Chr | Focal SNP statistics | Sweep region statistics | |||
| Location | nSL | Closest plausible genetic driver | Gene ID | Distance* | |
| 04 | 531,138 | 3.220 | Hypothetical proteins | — | — |
| 07 | 384,302 | 3.106 | Chloroquine resistance transporter (CRT) | PF3D7_0709000 | 18,920 |
| 11 | 1,089,187–1,347,798 | 3.024 | Phosphatidylinositol-4-phosphate 5-kinase; apical membrane antigen 1 (AMA1) | PF3D7_1129600; PF3D7_1133400 | 51,935; −93,151 |
| 13 | 2,550,178 | 2.924 | Hypothetical proteins | — | — |
| 06 | 1,093,476 | 2.871 | Hypothetical proteins | — | — |
| 14 | 610,371 | 2.805 | Hypothetical proteins | — | — |
| 06 | 825,473 | 2.730 | Merozoite surface protein 10 (MSP10) | PF3D7_0620400 | −25,905 |
| 09 | 203,308 | 2.656 | Hypothetical proteins | — | — |
| 12 | 124,649 | 2.652 | Dynein heavy chain, putative | PF3D7_1202300 | 0 |
| 13 | 639,213 | 2.597 | Transcription factor MYB1 (MYB1) | PF3D7_1315800 | −20,805 |
| 02 | 374,197 | 2.589 | Serine repeat antigen 1 (SERA1) | PF3D7_0208000 | 48,474 |
| 03 | 361,403 | 2.571 | Hypothetical proteins | — | — |
| 13 | 1,775,996 | 2.563 | Kelch protein K13 (K13) | PF3D7_1343700 | 48,999 |
| 01 | 226,924 | 2.505 | Hypothetical proteins | — | — |
| 09 | 513,729 | 2.489 | Cysteine repeat modular protein 1 (CRMP1) | PF3D7_0912000 | 0 |
Results are presented by ranking on absolute normalized nSL score.
*
Distance in bases from focal SNP to the putative driver gene; a negative sign indicates putative driver gene occurs upstream of the focal SNP; a zero indicates focal SNP occurs within the putative driver gene.