Table S1.

siRNA library used in this study

Characteristic	Gene number
NACHT domain	24
LRR domain	200
PADD_DAPIN domain	22
CARD domain	33
SPRY domain	80
BIR domain	8
IFN-inducible genes	60
Location: peroxisome	50
Total	477

The siRNA library was designed to target IFN-inducible genes and genes with functional domains implicated in regulating innate immune responses such as the NACHT domain, leucine-rich repeat domain, DAPIN domain, CARD domain, B30.2/SPRY domain, BIR domain, and genes localized to the peroxisome. The siRNA library includes 477 genes. Each gene is targeted by four independent siRNAs to reduce off-target effects.