Table S1.

Sex-specific associations of SNPs taken forward for replication from discovery GWAS

Alcohol phenotype	SNP	Gene	Chr	Position	Effect allele	Other allele	Men			Women
							Effect*	SE	P value	Effect	SE	P value
Log g/d	rs780094	GCKR	2	27,594,741	T	C	−0.016	0.004	2.8 × 10−4	−0.014	0.003	2.0 × 10−5
Log g/d	rs197273	TANK	2	161,602,909	A	G	−0.018	0.004	6.5 × 10−5	−0.010	0.003	2.1 × 10−3
Log g/d	rs10950202	AUTS2	7	69,568,034	C	G	0.022	0.006	5.7 × 10−4	0.017	0.005	5.1 × 10−4
Log g/d	rs11940694	KLB	4	39,091,388	A	G	−0.019	0.004	2.3 × 10−5	−0.011	0.003	8.9 × 10−4
Log g/d	rs350721	ASB3	2	52,833,931	C	G	0.023	0.007	5.7 × 10−4	0.020	0.005	5.7 × 10−5
Log g/d	rs6943555	AUTS2	7	69,806,023	A	T	−0.013	0.005	9.9 × 10−3	−0.011	0.004	3.3 × 10−3
Dichotomous	rs12599112	CDH13	16	81,276,212	A	C	0.053	0.091	0.561	−0.063	0.015	2.4 × 10−5
Dichotomous	rs10927848	TMEM82	1	15,948,493	A	G	0.027	0.036	0.452	−0.023	0.008	2.5 × 10−3

Chr, chromosome; EAF, effect allele frequency; CDH13, Cadherin 13; TMEM82, Transmembrane protein 82.

^*Effect refers to beta coefficient from linear regression for log grams per day alcohol phenotype and log(odds ratio) from logistic regression for dichotomous alcohol phenotype.