Table S2.

Dichotomous trait replication results

SNP	Chr	Position (hg19)	Gene*	Discovery P	Replication P	Overall P	Overall N
rs12599112	16	82,718,711	CDH13	2.3 × 10−8	0.895	5.0 × 10−8	86,213
rs10927848	1	16,075,906	TMEM82	2.6 × 10−7	0.291	1.9 × 10−7	103,219

Cohorts: the Airwave Health Monitoring Study (Airwave), the Austrian Stroke Prevention Study (ASPS), the British 1958 birth cohort (B58C), the Finnish Twin Cohort replication sample (FinnTwin_replication), the Genetic Regulation of Arterial Pressure of Humans in the Community Study (GRAPHIC), the Generation Scotland: Scottish Family Health Study (GS:SFHS), the INGI– Carlantino study (INGI_CARL), the INGI– Friuli Venezia Giulia study (INGI_FVG), the INGI–Val Borbera study (INGI_VB), the Lothian Birth Cohort 1921 (LBC1921), the Lothian Birth Cohort 1936 (LBC1936), and the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). The most significant SNP per locus is displayed. Chr, chromosome; CDH13, Cadherin 13; TMEM82, Transmembrane protein 82.

^*Loci are named according to the closest gene based on the position of the most significant SNP.