Table 1.

Associations of SNPs with alcohol intake (log grams per day) in the GWAS analysis

SNP	Chr	Position (hg 19)	Nearest gene	Effect/other alleles	EAF	Discovery GWAS		Replication		Combined
						Beta (SE)	P value	Beta (SE)	P value	Beta (SE)	P value	N
rs780094	2	27,741,237	GCKR	T/C	0.40	−0.0155 (0.0026)	3.6 × 10−9	0.0035 (0.0029)	0.238	−0.0102 (0.0019)	1.6 × 10−7	98,679
rs350721	2	52,980,427	ASB3	C/G	0.18	0.0206 (0.0040)	3.2 × 10−7	−0.0000 (0.0042)	0.994	0.0109 (0.0029)	1.9 × 10−4	100,859
rs197273	2	161,894,663	TANK	A/G	0.49	−0.0141 (0.0026)	9.8 × 10−8	−0.0058 (0.0028)	0.040	−0.0103 (0.0019)	7.4 × 10−8	97,631
rs11940694	4	39,414,993	KLB	A/G	0.42	−0.0137 (0.0027)	3.2 × 10−7	−0.0135 (0.0030)	5.2 × 10−6	−0.0136 (0.0020)	9.2 × 10−12	98,477
rs6943555	7	698,060,23	AUTS2	A/T	0.29	−0.0115 (0.0030)	1.4 × 10−4	−0.0070 (0.0033)	0.032	−0.0094 (0.0022)	1.9 × 10−5	104,282
rs10950202	7	69,930,098	AUTS2	G/C	0.16	−0.0194 (0.0038)	2.9 × 10−7	−0.0015 (0.0042)	0.720	−0.0113 (0.0028)	5.9 × 10−5	105,639

One SNP with the smallest P value was taken forward per region. Chr, chromosome; EAF, effect allele frequency in the discovery GWAS.