Fig. 2.

Increased in vivo FL levels rescue B-cell generation in Il7^−/− mice. (A) Representative FACS plots of EPLM (Upper) and CLP (Lower) from WT, Il7^−/−, Flt3ltg, and Flt3ltg-Il7^−/− mice. (B) Numbers of EPLM (Upper Left), CLP (Lower Left), Ly6D⁺ EPLM (Upper Right), and Ly6D⁺ CLP (Lower Right) from the mouse genotypes indicated on the x axes. For each mouse genotype, mean ± SEM is shown. (C) Numbers of CD19⁺CD117⁺ (Upper Left), CD19⁺CD117⁻IgM⁻ (Upper Right), and CD19⁺IgM⁺ (Lower) bone marrow cells from the mice indicated on the x axes. For each mouse genotype, mean ± SEM is shown. (D) Numbers of CD19⁺CD21^highCD23^low marginal zone (Left) and CD19⁺CD21⁺CD23⁺ follicular (Right) B cells in the spleens of WT or mutant mice, as indicated on the x axes. For each mouse genotype, mean ± SD is shown. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001.