Fig. 5.

Aberrant Wnt5a–ROR signaling dysregulates the localization of PCP components and tight junctions in LE. (A, Left) 3D reconstruction of Vangl2 IF showing aberrant expression patterns in Wnt5a^d/d, Wnt5a^GOF, and Ror1^d/d/Ror2^d/d LE cells on the morning of day 4. (Right) Relative apicobasal distribution of Vangl2 in Vangl2^f/f mice which was altered in Wnt5a^d/d, Wnt5a^GOF, and Ror1^d/d/Ror2^d/d mice. (B) Comparison of aberrant apicobasal expression of Scrib in LE of Wnt5a^d/d, Wnt5a^GOF, and Ror1^d/d/Ror2^d/d mice. (C) Aberrant apicobasal expression of ZO-1 in LE of Wnt5a^d/d, Wnt5a^GOF, and Ror1^d/d/Ror2^d/d mice. (Scale bars, 10 µm.)