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Differences in processing an established common central domain and eliminating leader peptide (LP) in the biosynthesis of thiopeptide antibiotics. Route A, for monocyclic and nosiheptide-type bicyclic thiopeptide members that contain a trisubstituted pyridine-derived domain; and route B, for TSR-type bicyclic members that share a tetrasubstituted piperidine-derived domain.
