Table 2. Hormonal differencesa from the reference group (no preeclampsia) among offspring at 11–12 years by exposure to preeclampsia in uterob.
| Preeclampsia status | Clinically mild | Clinically moderate | Severe features |
|---|---|---|---|
| Difference (p-value) | Difference (p-value) | Difference (p-value) | |
| Girls (unit) | |||
| Testosterone Total (ng/dL) | -34.3 (<0.001) | -38.2 (<0.001) | 31.6 (<0.001) |
| DHEAS c (ug/dL) | 34.0 (<0.001) | 28.8 (<0.001) | -14.9 (0.011) |
| Androstenedione (ng/dL) | 3.94 (0.949) | -2.62 (0.765) | -5.10 (0.658) |
| IGF-I d (ng/mL) | -1.77 (0.940) | 2.22 (0.901) | -13.8 (0.605) |
| Boys (unit) | |||
| Testosterone Total (ng/dL) | 39.6 (0.005) | 26.0 (0.04) | 21.3 (<0.001) |
| DHEAS (ug/dL) | 8.1 (0.129) | 11.0 (0.072) | -53.0 (<0.001) |
| Androstenedione (ng/dL) | 1.06 (0.366) | -0.69 (0.835) | -2.36 (0.677) |
| IGF-I (ng/mL) | 34.7 (0.033) | 37.7 (0.043) | -34.4 (0.063) |
| Testicular volume (mL) | 1.061 (0.038) | 1.572 (0.012) | -0.105 (0.861) |
a Adjusted for maternal age and education (least square means)
bSee S2 Table for actual concentrations
c DHEAS = Dehydroepiandrosterone sulfate
d IGF-I = insulin-like growth factor 1