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TER of wild-type and mutant claudin-5 transductants. Wild-type claudin-5 transductants exhibited a significant fivefold increase in TER, and Mut4 (with random mutation) transductants had a fourfold increase; the other claudin-5 mutants had no significant alterations. Data are shown as means ± standard deviation (one-way analysis of variance combined with Bonferroni t tests; n = 3, P < 0.001).
