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. 2016 Dec 14;9:7563–7571. doi: 10.2147/OTT.S123986

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© 2016 Cheng et al. This work is published and licensed by Dove Medical Press Limited

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LPS-induced downregulation of α-catenin was dependent on NF-κB pathway.

Notes: (A) SW620 cells were harvested 30 min after incubation with LPS+Bay 11-7082, LPS alone, or PBS, degradation of I-κB was analyzed with Western blotting. (B) Expression of α-catenin in SW620 cells treated with LPS+Bay 11-7082, LPS alone, or PBS was analyzed by Western blotting. (C) Cell motility of SW620 cells treated with LPS+Bay 11-7082, LPS alone, or PBS was detected with transwell migration assay. Magnification is ×100. (D) Expression of α-catenin in SW620 cells transfected with pcDNA3.1-HA-p65 plasmid or pcDNA3.1 vector was analyzed with Western blotting.

Abbreviations: LPS, lipopolysaccharide; PBS, phosphate-buffered saline.