Table 4.
In vivo mucoadhesion properties of BH.2HCl mucoadhesive buccal tablets
| Formulations | Adhesion time (h) | Adhesion strength | Irritation | Bitterness | Disintegration |
|---|---|---|---|---|---|
| F1 | 1 | Slightly adhesive | Moderate | Moderate | High |
| F2 | 1.5 | Slightly adhesive | Moderate | Moderate | High |
| F3 | 2 | Slightly adhesive | Moderate | Moderate | High |
| F4 | >8 | Adhesive | Non | Non | Non |
| F5 | >8 | Adhesive | Non | Non | Non |
| F6 | >8 | Adhesive | Non | Non | Non |
| F7 | 7 | Moderately adhesive | Non | Non | Slight |
| F8 | 6.5 | Moderately adhesive | Slight | Slight | Slight |
| F9 | 4.5 | Moderately adhesive | Slight | Slight | Moderate |
| F10 | >8 | Adhesive | Non | Non | Non |
| F11 | >8 | Adhesive | Non | Non | Non |
| F12 | >8 | Adhesive | Slight | Non | Non |
Abbreviation: BH.2HCl, betahistine dihydrochloride.