Table 5.
Ex vivo permeation parameters of BH.2HCl mucoadhesive buccal tablets
| Formulations | Qcum (µg/cm2) | Lag time (min) | Kp (cm/h) | EF |
|---|---|---|---|---|
| F10 | 3,255.84±150.47 | 51.08±4.81 | 0.0085±0.0012 | – |
| SCH | 3,874.56±195.41 | 42.11±3.67 | 0.0121±0.0032 | 1.42 |
| SDC | 3,453.60±114.78 | 48.05±2.49 | 0.0092±0.0017 | 1.08 |
| Menthol | 3,509.76±145.44 | 44.10±4.20 | 0.0090±0.0011 | 1.06 |
Note: Data are mean values (n=3) ± SD.
Abbreviations: BH.2HCl, betahistine dihydrochloride; EF, enhancement factor; Kp, permeability coefficient; SCH, sodium cholate hydrate; SDC, sodium deoxycholate; SD, standard deviation; Qcum, cumulative drug in the receptor compartment.