Table 7.

Mean pharmacokinetic parameters for the volunteers following administration of the optimized mucoadhesive buccal formulation and oral Betaserc^® tablets

Pharmacokinetic parameters	Mean ± SD
	F10	Betaserc tablet
Cmax (ng/mL)	106.31±9.12	151.95±10.28
tmax (h)	6.17±2.02	2.50±0.96
Kelim (h−1)	0.1022±0.0371	0.2235±0.0241
T1/2 (h)	6.78±0.87	3.10±0.23
AUC0–20 (ng·h/mL)	1,313.50±225.77	866.65±144.34
AUC0–∞ (ng·h/mL)	1,540.33±270.95	870.23±157.77
Frel (%)	177.00±11.02	–

Abbreviations: AUC, area under the curve; SD, standard deviation.