Table 1.
In vitro antimicrobial activity of free AZT, AZT-LPs, D-LPs, and AZT-D-LPs against S. aureus and E. coli strains
| Organism | Strains | MIC (μg/mL)
|
|||
|---|---|---|---|---|---|
| Free AZT | AZT-LPs | D-LPs | AZT-D-LPs | ||
| S. aureus | ATCC 25923 | 0.25 | 0.125 | .256 | 0.125 |
| ATCC 33591 | 0.5 | 0.25 | >256 | 0.25 | |
| Clinically isolated Sau2 | 512 | 256 | >256 | 256 | |
| Clinically isolated Sau5 | 512 | 256 | >256 | 256 | |
| Clinically isolated Sau7 | 512 | 256 | >256 | 256 | |
| Clinically isolated Sau9 | 256 | 256 | >256 | 256 | |
| Clinically isolated Sau3497 | 4 | 4 | >256 | 4 | |
| E. coli | ATCC 25922 | 0.5 | 0.5 | 128 | 0.5 |
| Clinically isolated E. coli | 128 | 128 | >256 | 128 | |
Abbreviations: ATTC, American Type Culture Collection; AZT, azithromycin; AZT-LPs, AZT-modified liposomes; D-LPs, DP7-C-modified blank LPs; AZT-D-LPs, DP7-C-modified AZT-loaded LPs; S. aureus, Staphylococcus aureus; E. coli, Escherichia coli.