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. 2016 Dec 13;9:7503–7513. doi: 10.2147/OTT.S115268

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© 2016 Souza e Silva et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Progression-free survival based on CTC kinetics and the status of the KRAS mutation.

Notes: Continuous line: patients with wild type KRAS and favorable kinetics (CTC1+ and CTC2−; 14.7 months). Dotted line: patients with mutant KRAS and favorable kinetics (CTC1+ and CTC2−; 5.3 months). Dashed line: patients with wild-type and unfavorable kinetics (CTC1− and CTC2+; 9.4 months). Dashed-dotted line: patients with mutant KRAS and unfavorable kinetics (CTC1− and CTC2+; 2.4 months) (P=0.02).

Abbreviation: CTC, circulating tumor cell.