Table 2.
Particle size distribution, ZP, water content, true density, and surface area of bosentan microparticles (mean ± standard deviation, n=3)
| Formulation | Z-average (d, µm) (PDI) | ZP (mV) | Water % | True density (g/cm3) | Surface area (m2/g) |
|---|---|---|---|---|---|
| Raw bosentan hydrate | 3.1 (1.0) | −43.4±1.5 | 3.5 | 1.3±0.0 | 2.9±0.0 |
| SD 1% | 2.2 (0.8) | −27.2±4.1 | 1.9 | 1.3±0.0 | 0.0±0.0* |
| SD 3% | 2.5 (0.6) | −16.7±5.0 | 2.3 | 1.3±0.0 | 0.5±0.1 |
| SD 5% | 2.7 (0.7) | −26.2±8.4 | 1.6 | 1.3±0.0 | 0.5±0.0 |
| JM 0.2 | 2.6 (0.7) | −42.4±2.0 | 3.7 | 1.3±0.0 | 3.2±0.1 |
| JM 0.3 | 2.8 (0.9) | −41.4±0.6 | 3.8 | 1.3±0.0 | 3.4±0.1 |
| JM 0.4 | 1.7 (0.7) | −42.6±0.5 | 3.9 | 1.3±0.0 | 3.8±0.1 |
Note:
*
P-value of <0.05.
Abbreviations: JM, jet milling; PDI, polydispersity index; SD, spray drying; ZP, zeta potential.