Table 3.
Aerosol performance characteristics of bosentan microparticles including ED, FPF, RF, MMAD and GSD (mean ± standard deviation, n=3)
| Formulation | Aerosol performance parameters
|
||||
|---|---|---|---|---|---|
| ED (%) | FPF (%) | RF (%) | MMAD (µm) | GSD | |
| Raw bosentan hydrate | 90.9±6.5 | 28.2±7.1 | 49.8±9.3 | 6.2±0.9 | 2.5±2.1 |
| SD 1% | 97.0±4.7 | 14.0±1.9 | 22.4±3.7 | 7.3±0.1 | 1.2±0.0 |
| SD 3% | 96.7±5.6 | 19.3±4.4 | 27.6±7.4 | 7.2±0.3 | 1.2±0.0 |
| SD 5% | 98.7±0.6 | 15.4±2.2 | 25.8±3.7 | 7.1±0.1 | 1.2±0.0 |
| JM 0.2 | 94.2±7.8 | 28.2±4.0 | 51.7±5.8 | 5.8±1.0 | 4.2±2.6 |
| JM 0.3 | 96.7±3.2 | 23.0±1.6 | 45.3±2.7 | 6.7±0.1 | 1.2±0.0 |
| JM 0.4 | 95.6±3.0 | 33.8±2.3 | 56.8±2.0 | 5.0±0.3 | 5.6±0.3 |
Abbreviations: ED, emitted dose; FPF, fine particle fraction; GSD, geometric standard deviation; JM, jet milling; MMAD, mass mean aerodynamic diameter; RF, respirable fraction; SD, spray drying.