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Tumor blood vessels markedly upregulate FN and αSMA. (A) Normal pancreatic islet (bracket) surrounded by exocrine tissue. Cells were stained to detect FN (red) and αSMA (green), and the overlap between the two is shown in yellow. Note that in normal tissue, expression of αSMA could be found only around arterioles (arrowhead). (B) A tumor section from a Rip-Tag transgenic mouse, wild type for FN. Both FN and αSMA are highly upregulated around the tumor vasculature. Bars, 10 μm.
