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. 2004 Oct;24(19):8662–8670. doi: 10.1128/MCB.24.19.8662-8670.2004

FIG. 6.

FIG. 6.

Islet tumorigenesis in the absence of EIIIB- or EIIIA-FN. (A) EIIIB−/− and EIIIB+/− Rip-Tag transgenic mice. The numbers of angiogenic islets isolated from 12-week-old Rip-Tag transgenic mice are shown (n is the number of animals used). (B) Tumor burden at 12 weeks of age. Tumor burden per mouse is the sum of volumes of all tumors in a mouse. (C) EIIIA−/− and EIIIA−/+ Rip-Tag transgenic mice. The numbers of angiogenic islets isolated from 11-week-old transgenic mice are shown. (D) Tumor burden at 11 weeks of age. Tumor burden was also assessed in 13-week-old animals on the mixed background, as well as in animals bred onto the BALB/c genetic background. Three independent experiments showed no statistically significant differences in the extent of the tumor growth between EIIIA−/− and EIIIA+/− animals (data not shown). Data from one experiment are shown. In this figure, P is the probability that the null hypothesis is true, as calculated by a two-tailed Student's t test. P values calculated according to the Wilcoxon sum-of-ranks test were 0.15, 0.12, 0.93, and 0.35 for panels A, B, C, and D, respectively. See Materials and Methods for information on the method used to generate the box plot.