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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Shock. 2017 Jan;47(1):52–60. doi: 10.1097/SHK.0000000000000721

Figure 4. Neutralization of OPN reduces renal histologic injury.

Figure 4

Sections of kidney tissue from sham, vehicle, IgG control, and anti-OPN Ab treated mice were collected after RIR and stained with H&E. (A) Representative sections are shown at 200× magnification. (B) Histologic injury grading score as described in Materials and Methods. The score represents the percentage of morphologic alterations as follows: 1, <10%; 2, 10–25%; 3, 26–50%; 4, 51%–75%; 5+, >75%. Data are expressed as mean ± SEM (n=10 microscopic fields/group) and compared by one-way ANOVA by SNK method. *p<0.05 vs. sham; #p<0.05 vs. vehicle; ψp<0.05 vs. IgG. H&E, hematoxylin and eosin; OPN, osteopontin.