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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Nat Rev Mol Cell Biol. 2016 Nov 3;18(1):31–42. doi: 10.1038/nrm.2016.132

Figure 4. m6A and other mRNA post-transcriptional modifications.

Figure 4

a| Qualitative distribution profiles of N1-methyladenosine (m1A; purple) and N6-methyladenosine (m6A; red) in mRNA. m1A is found primarily near translation start codons and first splice sites108, whereas m6A is primarily found in long exons and within 3′ untranslated regions (3′ UTRs)49. b | In addition to m6A and m1A, other chemical modifications found on eukaryotic mRNA with emerging regulatory functions include 5-methylcytosine (m5C), pseudouridine (ψ) and 2′-O-methylation (2′OMe). CDS, coding DNA sequence.