Table 2.
Associations between breast cancer susceptibility loci and measures of TDLU involution with statistically significant associations (P<0.05) among women in the Komen Tissue Bank and BREAST Stamp Project.
| SNP | Chr | Locus | TDLU counts |
Acini count per TDLU |
(TDLU counts)* (acini count per TDLU) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| RR* | (95% CI)* | P-trend* | RR* | (95% CI)* | P-trend* | RR* | (95% CI)* | P-trend* | |||
| rs616488 | 1 | PEX14 | 1.16 | (1.00,1.35) | 0.047 | 1.08 | (0.95,1.22) | 0.239 | 1.07 | (0.86,1.33) | 0.550 |
| rs1353747 | 5 | PDE4D | 1.00 | (0.80,1.25) | 0.981 | 1.28 | (1.07,1.54) | 0.007 | 1.40 | (1.05,1.88) | 0.024 |
| rs11242675 | 6 | FOXQ1 | 1.13 | (1.00,1.28) | 0.045 | 1.10 | (0.98,1.23) | 0.108 | 1.15 | (0.97,1.37) | 0.102 |
| rs204247 | 6 | RANBP9 | 0.93 | (0.82,1.05) | 0.259 | 0.92 | (0.82,1.03) | 0.144 | 0.81 | (0.67,0.96) | 0.017 |
| rs6472903 | 8 | 8q21.11 | 1.06 | (0.87,1.29) | 0.563 | 1.18 | (1.02,1.36) | 0.027 | 1.08 | (0.85,1.38) | 0.515 |
| rs6001930 | 22 | MKL1 | 1.24 | (1.02,1.50) | 0.031 | 1.10 | (0.92,1.33) | 0.292 | 1.30 | (0.99,1.72) | 0.058 |
TDLU: Terminal duct lobular unit; SNP: Single nucleotide polymorphism; Chr: Chromosome; RR: Risk ratio; CI: Confidence interval.
*
Based on a multivariable Poisson regression model with robust variance adjusted for study and age (in categories: <30, 30-39, 40-49, 50-59, ≥60) and an offset variable accounting for the tissue area on the slide (in log scale). SNPs were modeled using additive coding for the number of breast cancer risk alleles (0, 1, 2).