Table 3.
Associations between breast cancer susceptibility loci and TDLU counts by menopausal status (SNPs with P<0.05) among women in the Komen Tissue Bank and BREAST Stamp Project.
| SNP | Chr | Locus | Premenopausal* |
Postmenopausal* |
P-heterogeneity** | ||||
|---|---|---|---|---|---|---|---|---|---|
| RR | 95% CI | P-trend | RR | 95% CI | P-trend | ||||
| rs616488 | 1 | PEX14 | 1.19 | (1.01,1.41) | 0.040 | 1.10 | (0.81,1.50) | 0.548 | 0.617 |
| rs6678914 | 1 | LGR6 | 0.87 | (0.75,1.02) | 0.094 | 1.28 | (0.95,1.71) | 0.101 | 0.027 |
| rs6828523 | 4 | ADAM29 | 1.33 | (1.07,1.66) | 0.011 | 0.74 | (0.45,1.22) | 0.236 | 0.036 |
| rs11242675 | 6 | FOXQ1 | 1.18 | (1.03,1.35) | 0.020 | 1.05 | (0.79,1.38) | 0.749 | 0.363 |
| rs1011970 | 9 | CDKN2A/B | 0.94 | (0.75,1.18) | 0.617 | 1.43 | (1.03,1.98) | 0.031 | 0.032 |
| rs11199914 | 10 | 10q26.12 | 1.04 | (0.89,1.21) | 0.633 | 0.71 | (0.52,0.98) | 0.036 | 0.037 |
| rs3817198 | 11 | LSP1 | 0.83 | (0.71,0.97) | 0.022 | 1.08 | (0.76,1.52) | 0.669 | 0.165 |
| rs1292011 | 12 | TBX3 | 0.93 | (0.80,1.09) | 0.381 | 0.74 | (0.55,0.99) | 0.044 | 0.164 |
| rs6001930 | 22 | MKL1 | 1.32 | (1.08,1.61) | 0.006 | 0.93 | (0.53,1.63) | 0.808 | 0.267 |
TDLU: Terminal duct lobular unit; SNP: Single nucleotide polymorphism; Chr: Chromosome; RR: Risk ratio; CI: Confidence interval.
*
Based on a multivariable Poisson regression model with robust variance adjusted for study and age (in categories: <30, 30-39, 40-49, 50-59, ≥60) and an offset variable accounting for the tissue area on the slide (in log scale). SNPs were modeled using additive coding for the number of breast cancer risk alleles (0, 1, 2).
**
P-heterogeneity was computed as the P-value associated with the interaction term between menopause and the corresponding SNP