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Antimetastatic activity of pCQ in experimental 4T1 lung metastasis model. 4T1 cells were injected i.v. in Balb/c mice, followed by 4 i.v. doses of pCQ or HCQ. L = low dose (10 mg/kg HCQ equivalent, H = high dose (30 mg/kg HCQ equivalent). (A) Total number of surface lung metastases. Results shown as average of total number of surface lung mets ± SD (n = 8) (** p<0.01; *** p<0.001). (B) Representative images of the whole lung and H&E staining of the lung tissue sections (4× and 10×).
