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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: J Neurosci Res. 2016 Jun 19;95(8):1548–1564. doi: 10.1002/jnr.23778

Fig. 3.

Fig. 3

Conditional neuronal expression of Aβ induces progressive sleep loss. (A to C) Comparison of daytime profile in w; UAS-Aβ42; GeneSwitch-elav-GAL4 (Aβ42; GS-elav) flies treated (+) or untreated (−) with RU486 assessed as minutes (min) of Sleep (A and B), and Pixels Moved (C) during the 12 hour light period across 3 days (d1, d2, and d3). (D) Comparison of activity profile in Aβ42; GS-elav flies treated (+) or untreated (−) with RU486 assessed as pixels moved during the night period across 3 days. (n = 14 per group; p<0.001 two-way ANOVA, factors DAY and RU486 treatment, post-hoc Holm-Sidak). *P < 0.05, **P < 0.01, ***P < 0.001. Values represent means +/− SEM. ZT, zeitgeber time.