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Vn binding by bacterial pathogens. (A) Hsf of H. influenzae binds to the HBD3 of Vn. By recruiting Vn to the bacterial surface, H. influenzae inhibits formation of the MAC. (B) Multiple bacteria can bind Vn at different sites as indicated by the gray rectangles. Bacterial pathogens either interact with Vn's connecting region or with the C-terminal HBD3. Figure was produced using Servier Medical Art.
