Table 2. Changes in β-cell function and insulin resistance.
| Parameter | Sulfonylurea-maintenance (n=31) | Sulfonylurea-reduction (n=26) | Between-group P value | ||||
|---|---|---|---|---|---|---|---|
| Baseline | 6 Months | P value | Baseline | 6 Months | P value | ||
| AUCg, mmol/L·hr | 37.0±0.8 | 32.4±1.5 | 0.002 | 35.6±1.2 | 32.5±1.0 | 0.069 | 0.143 |
| AUCi, pmol/L·hr | 209.0±25.1 | 245.2±23.9 | 0.022 | 177.8±22.2 | 241.7±25.1 | 0.016 | 0.178 |
| AUCi/AUCg | 5.6±0.7 | 7.4±0.8 | 0.003 | 5.9±0.6 | 7.5±0.8 | 0.009 | 0.404 |
| HOMA-IR | 3.4±0.4 | 2.9±0.4 | 0.068 | 2.3±0.4 | 2.1±0.4 | 0.428 | 0.275 |
| Insulinogenic index | 4.6±0.8 | 6.9±1.2 | 0.031 | 5.7±1.2 | 16.3±6.4 | 0.045 | <0.001 |
| ISI composite (Matsuda index) | 7.4±1.5 | 7.7±1.5 | 0.714 | 8.0±1.3 | 8.3±1.3 | 0.812 | 0.696 |
Values are presented as mean±standard error.
AUCg, area under the response curve of glucose; AUCi, area under the response curve of insulin; HOMA-IR, homeostatic model assessment of insulin resistance; ISI, insulin sensitivity index.