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. 2016 Dec 20;10:287. doi: 10.3389/fncel.2016.00287

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Copyright © 2016 Kaliszewski, Kennedy, Blaes, Shaffer, Knott, Song, Hauser, Bossy, Huang and Bossy-Wetzel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Superoxide dismutase 1 (SOD1) knockout abolishes lysine 123-acetylated SOD1 (Ac-K123) antibody binding. (A) Western blot of brain tissue lysates from Sod1^+/+ and Sod1^−/− mice probed with Ac-K123 SOD1 (R25), SOD1 (FL-154) and α-Tubulin (DMA1) antibodies. (B) Confocal micrographs (scale bar, 200 μm) of Sod1^+/+ and Sod1^−/− mouse cerebellum sagittal sections showing Ac-K123 SOD1 (R26) immunostaining, nuclear Hoechst 33342 labeling or merged image. The granular cell layer (GCL) and molecular layer (ML) of the cerebellar cortex are identified. Below each image is a higher magnification confocal micrograph (scale bar, 10 μm) of the GCL and ML. Insets show a 2.5× zoom of the boxed region.