Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 20;10:287. doi: 10.3389/fncel.2016.00287

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Kaliszewski, Kennedy, Blaes, Shaffer, Knott, Song, Hauser, Bossy, Huang and Bossy-Wetzel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Distribution of Ac-K123 SOD1 within dentate gyrus granule cells and cornus ammonis field 1 (CA1) hippocampal neurons. (A) Sagittal view micrograph montage (scale bar, 200 μm) of the hippocampal region immunostained with Ac-K123 SOD1 (R26) antibodies. Areas of interest include the subiculum (Sub), fimbria (Fim), corpus callosum (CC), cortex (CTX), lateral ventricle (VL), dentate gyrus (DG), hippocampus CA1 and hippocampus CA3 field (CA3). Ac-K123 SOD1 labeling within cells lining the ventricle wall is also shown (arrows). (B) Confocal micrograph (scale bar, 100 μm) of the dentate gyrus and CA1 field of the hippocampus proper labeled with Ac-K123 SOD1 (R26) antibodies and Hoechst 33342. Dentate gyrus regions include the granule layer (GL), polymorphic layer (PM) and ML. The CA1 layers shown are the stratum pyramidale (SP), stratum radiatum (SR) and stratum lacunosum-moleculare (SLM). (C) Confocal micrograph (scale bar, 20 μm) of hippocampus CA1 field pyramidal neurons immunostained with antibodies against Ac-K123 (R26) SOD1 and the adult neuron specific marker NeuN. (D) Confocal micrograph (scale bar, 20 μm) showing the GL of the dentate gyrus immunostained with antibodies against Ac-K123 SOD1 (R26) and doublecortin. Immature adult granule neurons are noted (arrows). Insets show a 2.5× zoom of the boxed regions of merged image.