Figure 1.

Unhealthy lifestyle vs. dementia and therapeutical approach. (A) Hypothetical scheme representing how an unhealthy lifestyle could change the cell environment, triggering imbalanced cell signaling and lossing intrinsic regulation (altered saturated/unsaturated phospholipid composition, spreading of excitotoxicity, kinases/phosphates disbalance, pro-inflammatory response). Which could generate progressive affection of systemic functions (v.gr. metabolic disorders, diabetes, hypertension, atherosclerosis), in general; and cerebral dysfunction in particular, inducing loss of connectivity, vascular cogntivie impairment and dementia. (B) Convergent disbalance events in the brain after acute or chronic injury, which could be blocked by change of habits, or pharmacological and gene therapies in pivotal events (blue bars). (C) Being the main difficulty to define the inclusion criteria and the intervention time for translational approach, but highlighting the diverse therapeutical windows opportunities and phases of prevention of brain impairment.