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. 2016 Dec 20;9:135. doi: 10.3389/fnmol.2016.00135

Figure 2.

Figure 2

Inhibition by minocycline (MC) on ketamine-induced injury. (A) Ketamine induced a dose-dependent damage. NSCs were exposed to 10–200 μM/L ketamine for 24 h, then cell viability was measured by Cell Counting Kit-8 (CCK-8) assay. (B) MC prevented ketamine-induced injury dose-dependently. NSCs were exposed to different concentrations of 10–100 μM/L MC for 30 min before the addition of 100 μM/L ketamine. Cell viability was measured by CCK-8 assay at 24 h after ketamine addition. Data, as expressed percentage of control (Con), are the mean ± SEM of four separate experiments (n = 6 for each group). *p < 0.05 and **p < 0.01 vs. control; ▲P < 0.05 and ▲▲P < 0.01 vs. ketamine.