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. 2016 Oct 14;8(4):231–238. doi: 10.1038/ijos.2016.34

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Copyright © 2016 The Author(s)

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Interspecies competition between alr mutant and S. sanguinis in dual-species biofilms. (a) S. mutans (green), alr mutant strain (Δalr, green) and S. sanguinis (red) were labelled using species-specific fluorescent in situ hybridization probes. (b) The ratio of S. mutans/S. sanguinis quantified using the coverage area of each species. The results were averaged from at least five randomly selected positions of each sample and shown as the mean±standard deviation. *P<0.05, **P<0.01, ***P<0.0001. Δalr, S. mutans alr mutant; S.m, S. mutans; S.s, S. sanguinis.