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Proposed gene therapies for neuroprotection against Parkinson’s disease (PD). Based on the identified causes and risk factors for PD, various strategies have been envisaged, including RNA interference against α-synuclein and Parkin overexpression. Gene transfer has been proposed to deliver neurotrophic factors to rescue dopaminergic function, factors to suppress endoplasmic reticulum (ER) stress, enhance lysosomal and mitochondrial activities.
