Table 3.
CCA-IMT association with cardiovascular risk factors
| Model 1 |
Model 2 |
Model 3 |
||||
|---|---|---|---|---|---|---|
| Estimate (SE) | p Value | Estimate (SE) | p Value | Estimate (SE) | p Value | |
| Sex, men | 0.030 (0.003) | <0.001 | 0.028 (0.003) | <0.001 | ||
| Age, 5 years | 0.039 (0.001) | <0.001 | 0.036 (0.001) | <0.001 | ||
| TC, mmol/L | 0.004 (0.001) | <0.01 | 0.004 (0.001) | <0.01 | 0.002 (0.001) | 0.08 |
| Log TG, mmol/L | 0.017 (0.002) | <0.001 | −0.002 (0.003) | 0.51 | −0.002 (0.003) | 0.44 |
| Log CRP, mg/L | 0.008 (0.001) | <0.001 | 0.000 (0.001) | 0.73 | 0.000 (0.001) | 0.79 |
| BMI, 5 units | 0.015 (0.001) | <0.001 | 0.011 (0.001) | <0.001 | 0.013 (0.001) | <0.001 |
| SBP, 10 mm Hg | 0.013 (0.001) | <0.001 | 0.012 (0.001) | <0.001 | 0.010 (0.001) | <0.001 |
| Former smoker (vs never smoked) | 0.017 (0.003) | <0.001 | 0.015 (0.003) | <0.001 | 0.013 (0.003) | <0.001 |
| Current smoker (vs never smoked) | 0.019 (0.003) | <0.001 | 0.020 (0.003) | <0.001 | 0.014 (0.003) | <0.001 |
| T2DM | 0.029 (0.006) | <0.001 | 0.008 (0.006) | 0.17 | 0.003 (0.006) | 0.61 |
| Family MI | 0.003 (0.003) | 0.26 | −0.001 (0.003) | 0.78 | −0.002 (0.002) | 0.53 |
| Physically active | −0.003 (0.002) | 0.19 | 0.005 (0.002) | 0.057 | 0.006 (0.002) | <0.05 |
| Elementary school (vs university education) | 0.017 (0.003) | <0.001 | 0.008 (0.003) | <0.05 | 0.005 (0.003) | 0.13 |
| High school (vs university education) | 0.010 (0.003) | <0.01 | 0.004 (0.003) | 0.21 | 0.003 (0.003) | 0.39 |
| Junior college (vs university education) | 0.003 (0.004) | 0.41 | −0.001 (0.004) | 0.90 | −0.002 (0.004) | 0.68 |
| Statin use | 0.018 (0.004) | <0.001 | 0.014 (0.005) | <0.01 | 0.008 (0.005) | 0.14 |
| Antihypertensive medication use | 0.007 (0.003) | <0.05 | −0.009 (0.003) | <0.01 | −0.012 (0.003) | <0.001 |
| CHD | 0.025 (0.007) | <0.001 | 0.023 (0.008) | <0.01 | 0.014 (0.008) | 0.057 |
| Minimal plaque | 0.029 (0.003) | <0.001 | ||||
| Significant plaque | 0.066 (0.005) | <0.001 | ||||
Model 1, age-adjusted and sex-adjusted analysis.
Model 2, multivariable-adjusted analysis including age, sex, TC, log TG, log CRP, BMI, SBP, smoking status, T2DM, family MI, physical activity, education level, statin use, antihypertensive medication use, CHD.
Model 3, model 2 plus carotid plaque category.
BMI, body mass index; CCA-IMT, common carotid artery intima-media thickness; CHD, coronary heart disease; CRP, C reactive protein; MI, myocardial infarction; NS, not significant; SBP, systolic blood pressure; T2DM, type 2 diabetes mellitus; TC, total cholesterol; TG, triglycerides.