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. 2016 Dec 20;4:84. doi: 10.1186/s40425-016-0193-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Spider plot of tumor burden changes during nivolumab therapy using irRECIST. Longitudinal changes of tumor burden during therapy are shown in reference to baseline, showing baseline tumor burden as 1.0. The scan time points with the appearance of new target lesions are indicated by larger markers