Table 1.

Participant timeline

Day number in relation to surgery day	−1	0	1	2	3	4	1 month telephone call
Informed consent	X
Inclusion/exclusion criteria	X	X
Randomisation		X
Study drug		X
AE and SAE registration and report		X	X	X	X	X	X
Blood ciclosporin concentration		X	X
Blood tests efficacy: P-cystatin C, P-creatinine	X		X	X	X	X
Analysis U-TIMP-2, U-IGFBP7, U-albumin/creatinine		X	X
Blood tests safety: Mg, K, urea, myoglobin, ASAT, ALAT, bilirubin, ALP, GT, leucocytes, CRP, CK, Hb, Trc	X		X	X	X	X
Exploratory immunological tests		X	X
Blood tests cardiac: troponin T, CK MB	X	X	X	X	X
Blood test cerebral: S-S100B	X		X	X
Documentation of: hourly diuresis, bleeding at 12 hours and total, time to extubation, time in ICU, fluid balance		X	X
Temperature, blood pressure	X		X	X	X	X
Scoring leg wound infection.						X

Day −1 illustrates the day before surgery, usually the same as admission day, day 0 surgery day, day 1 the day after surgery, etc.

AE, adverse event; ALAT, alanine aminotransferase; ALP, alkaline phosphatase; ASAT, aspartate aminotransferase; CK, creatine kinase; CRP, C reactive protein; GT, γ-glutamyl transferase; Hb, haemoglobin; ICU, intensive care unit; IGFBP7, insulin-like growth factor binding protein 7; K, potassium; Mg, magnesium; SAE, serious adverse event; TIMP-2, tissue inhibitor of metalloproteinase 2; Trc, thrombocytes.