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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Int J Cancer. 2016 Jul 19;139(9):2116–2126. doi: 10.1002/ijc.30253

Figure 2. Leiodermatolide Induces Apoptosis in Pancreatic Cancer Cells.

Figure 2

a) The pancreatic cancer cell lines AsPC-1, PANC-1, BxPC3 and MIA PaCa2 were treated with 10 nM leiodermatolide for 1, 3, 6, and 24 hours followed by measurement of caspase 3 cleavage with the CaspaseGlo assay. Cleavage of caspase 3 was significant in the BxPC-3 and MIA PaCa2 cells after 24 hours of treatment with 10 nM leiodermatolide. The average of 3 experiments ± standard error of the mean is shown. b) The pancreatic cancer cell lines AsPC-1, PANC-1, BxPC3 and MIA PaCa2 were treated with 10 nM leiodermatolide for 24hours. Induction of apoptosis was determined by monitoring DNA fragmentation (TUNEL). Treatment with leiodermatolide induced DNA fragmentation in the AsPC-1, BxPC3 and MIA PaCa2 cells. The average of 3 experiments ± standard deviation is shown.