Skip to main content
. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Int J Cancer. 2016 Jul 19;139(9):2116–2126. doi: 10.1002/ijc.30253

Figure 5. Leiodermatolide Affects Tubulin Dynamics.

Figure 5

Time lapse photography of HeLa EB1-GFP cells was taken every 15 seconds for ten minutes to observe the addition of the GFP-tagged EB1 microtubule associated protein to the plus ends of the microtubules. At five minutes, treatments were added and photography continued. Treatments consisted of 1×, 10× or 30× the IC50 for leiodermatolide, 30× IC50 vincristine or DMSO. Treatment with leiodermatolide immediately caused cessation of GFP-EB-1 comets similar to, but faster than, that observed for the depolymerizing agent vincristine.