Figure 6. Leiodermatolide Exhibits Anti-tumor Effects.

Nude mice were injected with 1 million L3.6pl cells into the pancreas to induce tumors. Seven days later when tumors were well established, 10 mice were treated with 10 mg/kg leiodermatolide once per week for three weeks, 10 mice were treated with 100 mg/kg gemcitabine two times per week for five weeks and 10 mice received saline control. All treatments were delivered by intraperitoneal injection. Body weight was measured on the first day of treatment and each week thereafter. Tumor weight was determined on the day of termination. The experiment was conducted for 9 weeks. Leiodermatolide significantly reduced tumor weight when compared to gemcitabine treated or control mice, while exhibiting a similar survival curve as controls.