Table 1. Summary of genes targeted by diverse CRISPR/Cas9 strategies in mammalian neurons.
CRISPR manipulation | Gene targets | References |
Conditional knockout in neurons | Abhd6, Dnmt1, Dnmt3a, Dnmt3b, GRIA2, Grin1, GRIN1, Katnal2, Mecp2, Rbfox3, Top1, 3110043O21Rik | [57-59,150-154] |
Knockin of variant to neuronal gene | APP, FMR1, PSEN1 | [47,155] |
Deletion of cis-regulatory element | Prdm1 | [64] |
Activation of proximal and distal enhancers | Grin2c | [16] |
Repression of distal enhancers | Fos | [112] |
Knockin of small epitope tag for visualization | Actb, Arc, Camk2a, Cacna1c, CHAT, Dcx, Fmrp, GAD67, Mecp2, Prkca, Rab11a, Ywhae | [97,156,157] |