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. 2016 Dec 23;89(4):457–470.

Table 1. Summary of genes targeted by diverse CRISPR/Cas9 strategies in mammalian neurons.

CRISPR manipulation Gene targets References
Conditional knockout in neurons Abhd6, Dnmt1, Dnmt3a, Dnmt3b, GRIA2, Grin1, GRIN1, Katnal2, Mecp2, Rbfox3, Top1, 3110043O21Rik [57-59,150-154]
Knockin of variant to neuronal gene APP, FMR1, PSEN1 [47,155]
Deletion of cis-regulatory element Prdm1 [64]
Activation of proximal and distal enhancers Grin2c [16]
Repression of distal enhancers Fos [112]
Knockin of small epitope tag for visualization Actb, Arc, Camk2a, Cacna1c, CHAT, Dcx, Fmrp, GAD67, Mecp2, Prkca, Rab11a, Ywhae [97,156,157]