Figure 2.

MLL and SWI/SNF complexes. A) Representation of the MLL1 protein complex. MLL1 is expressed as a single protein but cleaved to an N- and C-terminal fragment by the enzyme, taspase. MLL2 has a similar subunit structure. MLL3 and MLL4 are not cleaved by taspase and are not associated with menin or LEDGF, but maintain association with WDR5, RBBP5. ASH2L and DPY30, and possess other unique subunits [99,105]. B) Generalized representation of a SWI/SNF complex. Several different complexes have been characterized with the alternatively exclusive presence of SMARCA2 or SMARCA4, and the presence of either ARID1A, ARID1B, or ARID2 plus PBRM [118].