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. 2016 Dec 23;89(4):591–596.

Figure 1.

Figure 1

Global redistribution of TF binding in T cells and AML cells in response to activation of receptor signaling. A. TCR signaling pathways linked to the activation of inducible genes such as GM-CSF in T cells. Shown underneath are TF motifs that were found to be enriched in a population of ~1000 inducible DHSs identified in a global analysis of stimulated mouse T cells [1]; B. Scale model of the chromatin architecture and TF occupancy at the human GM-CSFenhancer in T cells before and after activation of TCR signaling; C. Gene regulatory network activated via MAPK signaling pathways by FLT3, Ras and Raf gene mutations in AML. Shown underneath are TF motifs that were found to be enriched in a population of ~1000 DHSs that are specifically enriched in AML carrying FLT-ITD mutations [2].