Figure 2.

Mechanisms of establishing and maintaining immunological memory in T cells. A. Stages of T cell activation and differentiation; B. DNase-Seq and TF ChIP-Seq, plus motif locations, for 2 Kb segments of the mouse genome spanning the ~17,000 strongest DHSs in naïve CD4 T cells and CD4 T blast cells, ranked in order of increasing signal in T blast cells relative to naïve T cells [2]; C. Scale model depicting mechanisms of TF binding and epigenetic re-programming of activated and memory T cells.