Skip to main content
. Author manuscript; available in PMC: 2016 Dec 20.
Published in final edited form as: Nature. 2016 Jan 27;530(7588):57–62. doi: 10.1038/nature16546

Figure 2. Differentially regulated enhancers in medulloblastoma subgroups.

Figure 2

(a) ANOVA classification of medulloblastoma enhancers.

(b) Distribution of differentially regulated enhancers among medulloblastoma enhancer classes.

(c) K-means clustering of differentially regulated medulloblastoma enhancers (n=20,406).

(d) Proportion of enhancer/gene assignments to N enhancers.

(e) Proportion of enhancer/gene assignments to N genes.

(f) WNT-specific enhancer activity (rpm/bp) and expression (log2 RPKM, n=140) of ALK. Error bars represent standard deviation (s.d.) of the mean.

(g) Immunohistochemical validation of ALK expression in WNT medulloblastoma patients (n=49).